Science / Articles

Scientifc publications

  • Groth, D., Reszka, R. and Schenk, J.A.,(1996). PEG mediated transformation of E. coli is increased by room temperature incubation, Anal Bioch 240: 302-304.
  • Groth, D., Keil, O., Lehmann, C., Schneider, M., Rudolph, M., Reszka, R. (1998). Preparation and characterisation of a new lipospermine for gene delivery into various cell lines. Int J Pharm 162: 143-157.
  • Groth, D., Keil, O., Schneider, M., Reszka, R. (1998). Transfection assay for dual determination of toxicity and gene expression. Anal Bioch 258: 141-143.
  • Hinz, B., Groth, D., Rieck, P., Reszka, R., Hartmann, Chr. and Pleyer, U. (1999). Cationic lipid-mediated gene transfer and cytotoxicity studies of primary bovine cornea endothelial cells (BCEC). Invest. Ophthalmol. Vis, Sci. 40, S1999.
  • Armeanu S, Pelisek J, Krausz E, Fuchs A, Groth D, Curth R, Keil O, Quilici J, Rolland PH, Reszka R, Nikol S.Optimization of nonviral gene transfer of vascular smooth muscle cells in vitro and in vivo.Mol Ther. 2000 Apr;1(4):366-75.
  • Pleyer U, Groth D, Hinz B, Keil O, Bertelmann E, Rieck P, Reszka R. Exp Eye Res. 2001 Jul;73(1):1-7.
  • Hennig S, Groth D, Lehrach H. (2003). Automated Gene Ontology annotation for anonymous sequence data. Nucleic Acids Res. 2003 Jul 1;31(13):3712-5
  • Panopoulou G, Hennig S, Groth D, Krause A, Poustka AJ, Herwig R, Vingron M, Lehrach H. (2003). New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes.Genome Res. 2003 Jun;13(6A):1056-66.
  • Poustka AJ, Groth D, Hennig S, Thamm S, Cameron A, Beck A, Reinhardt R, Herwig R, Panopoulou G and Lehrach H (2003). Generation, Annotation, Evolutionary Analysis, and Database Integration of 20,000 Unique Sea Urchin EST Clusters. Genome Res. 2003;13 2736-2746
  • Groth D, Lehrach H, Hennig S (2004). GOblet: a platform for Gene Ontology annotation of anonymous sequence data. Nucl. Acids. Res. 2004 32: W313-W317
  • Adjaye J, Huntriss J, Herwig R, BenKahla A, Brink T, Wierling C, Hultschig C, Groth D, Yaspo M, Picton H, Gosden D, Lehrach H (2005). Primary differentiation in the human blastocyst: Comparative molecular portraits of inner cell mass and trophectoderm cells. Stem Cells Express, first published online August 4, 2005; doi:10.1634/stemcells.2005-0113
  • Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, Lehrach H, Zouboulis CC (2006). Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell (2006) 5, 331–344.
  • Babaie Y, Herwig R, Greber B, Brink TC, Wruck W, Groth D, Lehrach H, Burdon T and Adjaye J. Analysis of OCT4 dependent transcriptional networks regulating self renewal and pluripotency in human embryonic stem cells (2007). Stem Cells. 2007 Feb;25(2):500-10. Abstract

  • Poustka AJ, Kühn A, Groth D, Weise V, Yaguchi S, Burke RD, Herwig R, Lehrach H, Panopoulou G. A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks. Genome Biol. 2007;8(5):R85. Full Text
  • Adjaye J, Herwig R, Brink TC, Herrmann D, Greber B, Sudheer S, Groth D, Carnwath JW, Lehrach H, Niemann H. Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression. Physiol Genomics. 2007 Oct 22;31(2):315-27. Epub 2007 Jun 26. Abstract
  • Steinfath M, Groth D, Lisec, J, Selbig J. Metabolite profile analysis: from raw data to regression and classification (2008). Physiologia Plantarum 132: 150–161. Abstract
  • Hufton AL, Groth D, Vingron M, Lehrach H, Poustka AJ, Panopoulou G. Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement. Genome Res. 2008 Jul 14. [Epub ahead of print]
  • Groth D, Hartmann S, Panopoulou G, Poustka AJ and Hennig S. GOblet: Annotation of anonymous sequence data with Gene Ontology and Pathway terms. Journal of Integrative Bioinformatics, 5(2):104, 2008. Online Journal: Abstract und PDF



  • Groth, D., Lehmann, C., Keil, O., Schneider, M., Reszka, R.. (1998). Preparation and characterisation of cationic liposomes for gene transfer. In J.E. Diederichs, R.H. Müller (Eds), Future Strategies for Drug Delivery with Particulate Systems, medpharm GmbH Scientific Publishers and CRC Press, Stuttgart, pp 132-139.
  • Lehmann, C., Groth, D., Keil, O., Schneider, M., Rudolph, M. and Reszka, R., Characterization of gene transfer vesicle by electron microscopy in Diederichs, J.E., Müller, R.H. (Eds), Future Strategies for Drug Delivery with Particulate Systems, medpharm GmbH Scientific Publishers and CRC Press, Stuttgart, 1998, pp 140-145.


  • Schneider, M., Reszka, R., Groth, D., Keil, O. (1996). Neuartige kationische Amphiphile für den liposomalen Gentransfer. Deut Pat Applik 196 31 189.6.
  • Groth, D., Reszka, R., (1997). Verfahren zur dualen Bestimmung von Zellvitalität und Effizienz nach Gentransfer in eukaryontische Zellen Patent Nr. 197 50 790.